| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 가을 (10/09 ~ 10/10, 일산킨텍스) |
| 권호 |
33권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Encapsulation of Quantum dots with Mixture PEG-PCDA and PCDA-Herceptin conjugates for Targeted Cancer Imaging |
| 초록 |
Polymer based nanoparticles are now widely using for drug delivery and target therapy. We modified the surface of QDs in solid dispersion method by PEG-PCDA & PCDA-Herceptin conjugates to make it water soluble & target specific. Upon UV-irradiation, the core of QDs in micelles was further stabilized by intra-micelles cross-linking between neighboring PCDA moieties. The QDs micelles were spherical with diameters around 130nm. Herceptin is a humanized IgG monoclonal antibody which targets the epidermal growth factor receptor-2 (HER-2). In this study we successfully make a conjugates with highly fluorescent non-toxic QDs (CdSe/ZnS). HER-2 positive expressed breast cancer cell SK-BR3 shows brighter image than HER-2 negative expressed breast cancer cell MDA-MB231 & KB cell (non containing HER-2 receptor) due to having herceptin with this conjugate. |
| 저자 |
MD. Nurunnabi1, 허강무2, 최준식2, 이용규1
|
| 소속 |
1충주대, 2충남대 |
| 키워드 |
CdSe/ZnS Qds; PEG-PCDA conjugate; PCDA-Herceptin conjugate; Crosslinking; HER-2 receptor
|
| E-Mail |
|
