| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Endothelial cell membrane infused with a nitric oxide generating catalytic lipid and its tethering on titanium for the endo-vascular implantation |
| 초록 |
The present study was developed to investigate the potential use of lipid bilayer-coated titanium containing membrane extracted from endothelial cells (ECs) and phospholipid with a catalytic selenium molecule producing nitric oxide (NO) with endogenous NO precursors. We fused selenium containing molecule into membrane from ECs and sequentially inserted membrane into pre-tethered phospholipids on the titanium surface. The tethered lipid bilayer exhibited endothelium-mimetic properties and successfully generated NO. When three types of cells including EC, smooth muscle cell, and macrophage were cultured on lipid bilayer, lipid bilayer played a role in a promotive, suppressive, and immunomodulatory manner to each cell, respectively. Together, our results not only provide understanding of the characteristics of catalytic NO-releasing lipid and cellular responses to lipid bilayer but also highlight the development of versatile design for vascular implantation and bio-interfacing devices. |
| 저자 |
Mahmoud A. Elnaggar, Md. Lemon Hasan, 이주로, 정윤기
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| 소속 |
한국과학기술(연) |
| 키워드 |
lipid bilayer; tethering; nitric oxide; endo-vas
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| E-Mail |
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