| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ |
| 제목 |
Lipid bilayers infused with a nitrated lipid tethered on titanium for the intra-vascular implantation |
| 초록 |
In the present study, we investigate the potential use of tethered lipid bilayer (tLB) membranes infused with a nitrated lipid generating nitric oxide (NO) for the sustained release of NO from tLB membrane-anchored on a metal surface. The NO generating tLB membranes are produced via following two steps: 1) immobilization of phospholipids on a metal surface and 2) fusing liposomes containing nitrated lipid with the pre-tethered phospholipids on the surface. Our data demonstrated that the tLB membrane was successfully anchored on a titanium surface. The tLB membrane dramatically reduce the adsorption of non-specific protein binding compared with a bare titanium plate. The lipid bilayer released NO up to 24 hours. In addition, NO released from the tLB membrane enhanced the viability of endothelial cell cultured on the surface of tLB membrane in vitro. Together, our results pave the way for the potential use of tLB-coated surfaces in biomedical devices for therapeutic purposes. |
| 저자 |
Mahmoud A. Elnaggar, 이주로, 정윤기
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| 소속 |
한국과학기술(연) |
| 키워드 |
lipid bilayer; endothelial cell; nitric oxide; intra-vascular implant
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| E-Mail |
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