| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
대학원생 구두발표(영어발표, 발표15분) |
| 제목 |
Improved anti-inflammatory and angiogenic properties by nitric oxide released from gelatin hydrogel in chronic wound therapy |
| 초록 |
The chronic wound due to the extended inflammatory phase and the reduced vascularization has caused serious problems to human health. Currently, nitric oxide (NO) is an endogenous gas molecule that involves in many physiological processes. However, the clinical application of NO is limited due to their burst and short half-life release from the biomaterials. In this study, copper nanoparticles (a NO-generating catalyst) were incorporated in the gelatin-based hydrogel (GH) for in situ generation of NO in the presence of endogenous S-nitrosothiol. The fabricated hydrogel presented the sustained release of NO for over 3 weeks within the physiological level, which stimulated the in vitro anti-inflammatory and angiogenic properties. Besides, the chorioallantoic membrane and in vivo animal study also confirm the angiogenic activity of GH/Cu hydrogel. Overall, GH/Cu hydrogel presented as a promising material for wound healing treatment. Acknowledgement: 2019R1A6A1A11051471 & 202012A01 |
| 저자 |
Dieu Linh Tran1, Soi Kim1, Thi Phuong Le1, 박기동2
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| 소속 |
1Ajou Univ., 2아주대 |
| 키워드 |
hydrogel; nitric oxide; copper nanoparticles; anti-inflammation; angiogenesis
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| E-Mail |
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