| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Oral antigen delivery by β-glucan-TCA for targeting M-cells in small intestine and induce mucosal immunity |
| 초록 |
Oral vaccines encounter multifarious barriers, including acidic and enzymatic degradation, poor uptake, preventing the immune system to react to inoffensive environmental antigens. We designed an oral antigen delivery system, β-glucan-TCA where β-glucan can encapsulate antigen due to its hollow and porous structure, target β-glucan receptors in M-cells in small intestine and induce mucosal immunity, and TCA (taurocholic acid) helps the oral absorption of the carrier thus accelerate the process. The resultant microparticles were analyzed for their antigen loading efficacy, pH stability, in vitro cytotoxicity and cellular uptake capacity in M-cell model. The findings demonstrate that there is an efficient encapsulation of Ovalbumin as a key reference protein for vaccination experiments inside β-glucan-TCA core. The formulation is stable in various pH conditions and nontoxic for living cells. |
| 저자 |
Mohammad Nazmul Hasan1, Sungpil Cho2, 이용규1
|
| 소속 |
1한국교통대, 24D Biomaterials Center |
| 키워드 |
Oral antigen delivery; Beta glucan; Taurocholic acid; M-cell targeting; Mucosal immunity
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| E-Mail |
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