| 초록 |
Disk-shaped particles based on polycaprolactone (PCL) were synthesized using photodegradable polymethylvinylketone (PMVK) and used for drug delivery system. In this study, PCL based triblock copolymer was synthesized by RAFT polymerization and used to fabricate microsphere by emulsion-evaporation method. Disk-shaped particles were then prepared by UV-irradiation with the microsphere. In order to polymerize by RAFT method, PCL based macro-CTA (chain transfer agent) was first synthesized by reacting carboxylic acid-terminated CTA with PCL, and used for the synthesis of block copolymer with methyl vinyl ketone (MVK). The morphology of the particles before and after UV irradiation were confirmed by SEM and TEM images and the release behavior of paclitaxel, anti-cancer agent for female cancers, in disk shape particles were evaluated by HPLC. PCL based disk-shaped particles will be anticipated to enhance drug release and could find potential application for biomaterials. |
