| 초록 |
Sonodynamic therapy (SDT) has demonstrated significant therapeutic efficacy by penetrating deeply inherent tumor site using an exogenous energy source, ultrasound (US). Although SDT shows a promising property of tumor selectivity, the shortage of additional diagnostic process has restricted the clinical in vivo applications of SDT. Thus, combining image-guided system may allow SDT intraoperative tracking of current location and provide specialized surgical guidance. Here, we prepared PEGylated mesoporous sonosensitizers (PMSs) and loaded perfluorohexane (PFH) as a gas precursor. When exposed to US irradiation, PFH@PMSs generated a strong and prolonged photoacoustic signals in vivo, owing to the vaporization of PFH under temperature increase. Further, a significantly higher amount of ROS was produced, inducing the effective suppression of tumor growth. Taken together, PFH@PMSs mediated SDT represents a protective potential in clinical diagnostic approach and future cancer theranostics. |
