| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 | 25권 2호 |
| 발표분야 | 포스터-생체재료 |
| 제목 | Amphiphilic triblock copolymer-based dissolving microneedles in situ for cancer treatment |
| 초록 | Resiquimod is a specific ligand for human Toll-like receptor 7 and 8 (TLR7/8) and it will stimulate immune cells to induce cellular immune responses when used as an adjuvant, leading to strong antiviral and antitumor effects. But the poor solubility in an aqueous medium and systemic cytotoxicity limits the use of resiquimod. Among various types of MNs, dissolving MNs have attracted much attention due to their ease of preparation and improved safety. Dissolving MNs enable efficient cutaneous drug delivery via the rapid dissolution of the matrix upon contact with moisture in the intradermal region and minimize the risk of inflammation caused. In this study, the NMC-generating MNs based on the poloxamer was formulated with the combination of ovalbumin (OVA) and R848 as a model therapeutic cancer vaccine, the MNs showed enhanced antigen-specific humoral and cellular immune responses and significant antitumor activity in E.G7-OVA tumor-xenograft mice. |
| 저자 | LYU SIYAN, 박채은, 김병덕, 황위보, 김다훤, 임수연, 정지훈 |
| 소속 | 성균관대 |
| 키워드 | miconeedle; cancer vaccine |
