| 초록 |
A series of dual stimuli responsive synthetic polymer bioconjugate chimeric materials, poly(N-isopropylacrylamide)55-b-poly(L-histidine)n [p(NIPAM)55-b-p(His)n] (n =50, 75, 100, 125), have been synthesized by employing reversible addition−fragmentation chain transfer polymerization of NIPAM, followed by ring−opening polymerization of α-amino acid N-carboxyanhydrides. Uniform self-assembled micelles (∼55 nm) fabricated by p(NIPAM)55-b-p(His)n polymers display sharp thermal and pH responses in aqueous media. An anticancer drug, doxorubicin (Dox), is effectively encapsulated in the micelles and the controlled Dox release is investigated in different temperature and pH conditions. Antitumor effect of the released Dox is also assessed using the HepG2 human hepatocellular carcinoma cell lines. The self-assembling ability of these hybrid materials into uniform micelles and their efficiency to encapsulate Dox makes them a promising drug carrier to cancer cells. |
