| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 봄 (04/11 ~ 04/12, 대전컨벤션센터) |
| 권호 |
38권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Development of dual-functional nanofibrous scaffolds for skin tissue engineering |
| 초록 |
Recently, there are increasing social and ethical concerns regarding the use of animal test for property analysis of new chemicals, novel system for replacing animal testing model has been pursued in tissue engineering field. In this study, we developed PLCL nanofibrous scaffolds, and then AAc was grafted to introduce carboxylic acid group using r-ray irradiation. To increase biological function of the scaffolds, EGF and gelatin were further immobilized on the scaffolds. The properties of the scaffolds were analyzed by SEM, TBO uptake, ATR-FTIR, water contact angle measurement, ELISA and fluorescamine assay. During the 10 days of hMSC culture, adhesion, spreading, and proliferation were significantly increased on the dual-functional scaffolds, we also confirmed that differentiation to epidermal lineage was up-regulated on the EG-AP scaffolds. Therefore, our results suggest that dual-functional scaffolds may be presented as an alternative tool in skin tissue engineering. |
| 저자 |
임종영1, 신영민2, 정성인2, 박종석2, 권희정2, 신흥수3, 임윤묵2
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| 소속 |
1한국원자력(연), 2첨단방사선(연), 3한양대 |
| 키워드 |
tissue engineering; scaffolds; EGF; Gelatin; hMSC; PLCL
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| E-Mail |
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