| 초록 |
Hydrogel, widely used as a platform for drug delivery, has superior biocompatibility, structural stability, and adjustable physicochemical properties for stimuli-responsivity. However, using hydrogel for cancer therapy has remained a challenge since its release needs to be adjusted temporally and quantitatively so that the concentration of the drug exceeds the minimum effective concentration at proper time in the target site. Here, we report a hyaluronic acid hydrogel that is decomposed and releases the drug when exposed to ultrasound(US). The drug conjugated with polymer nanoparticles was coated with gold(AuNP), which acted as a crosslinker for dopamine-functionalized hydrogels(dopHA), forming dopHA-AuNP gel. The results confirmed that the prepared dopHA-AuNP gel effectively induced apoptosis of cancer cells in response to US of 30W or higher, and successfully cleaved AuNP binding to the drug, suggesting the potential of hydrogel-based sonothermal therapy and on-demand cargo release. |
