| 초록 |
In the recent decades, immunotherapy has been recognized as a promising therapeutic method for cancer treatment. To enhance host immune responses against cancer, antigen presenting cells such as dendritic cells (DCs) need to be activated using tumor-associated antigens and adjuvants, which induces a cascading adaptive immune response targeting tumor cells. Recently we found that injectable mesoporous silica particles could be spontaneously stacked in the subcutaneous space after injection and generate interparticular pores that could be served as cellular microenvironments to recruit and manipulate DCs. The subsequent direct delivery of nano-vaccines carrying protein antigen or antigen-coding DNAs to the recruited DCs significantly enhance antigen-specific T cell responses. These findings suggest that mesoporous silica could be used as an efficient delivery vehicle as well as cell-recruiting scaffold to induce enhanced cancer immunotherapy. |
