| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 Ⅰ,Ⅱ |
| 제목 |
Tumor-Responsive Polypeptide Micelles Incorporated with Pro-Oxidant Drug for Effective Cancer-Selective Therapy |
| 초록 |
The generation of reactive oxygen species (ROS) in cancer cells induces oxidative stress and has been utilized for cancer-specific therapy. Therefore, the development of ROS-responsive carriers carrying anticancer drugs into tumor sites is critical for cancer-specific therapy. Here, we fabricated an ROS-responsive poly(ethylene glycol)-poly(methionine) [PEG-P(Met)] integrated with piperlongumine (PL). The micelles containing hydrophobic PL into a P(Met) core were fabricated via self-assembly. Under ROS conditions, transformation from hydrophobic to hydrophilic stage of P(Met) occurred, leading to the disassembly of core-shell structure and PL release. PL-loaded PEG-P(Met) micelles [(PL-PEG-P(Met)] induced higher apoptosis in MCF-7 cells compared to free PL. Notably, PL-PEG-P(Met) micelles exhibited cancer-specific cytotoxicity in MCF-7 cells due to elevated intracellular ROS. In conclusion, ROS-responsive PEG-P(Met) micelles find significant potential for cancer-selective therapy. |
| 저자 |
Quan Hoang Truong1, Daeyong Lee2, Thuy Giang Nguyen Cao1, Yeu-Chun Kim2, 심민석1
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| 소속 |
1Incheon National Univ., 2KAIST |
| 키워드 |
polypeptide micelles; polymethionine; pro-oxidant drug; cancer therapy
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| E-Mail |
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