| 학회 | 한국공업화학회 |
| 학술대회 | 2018년 봄 (05/02 ~ 05/04, 대구 엑스코(EXCO)) |
| 권호 | 22권 1호 |
| 발표분야 | 생체재료_포스터 |
| 제목 | Heart targetted drug delivery via tannic acid modification |
| 초록 | Targeting drugs to the heart is a challenging, due to its dynamic mechanical motions and large blood flow. Therefore, most common drug administration to treat heart disease is a systemic injection into blood vessel. However, this method has a few drawbacks, such as non-target delivery, low delivery efficiency, and so on. To overcome these problems, we show that the modified therapeutic protein or peptide with tannic acid, which is a flavonoid found in plants that adheres to extracellular matrix, elastin and collagen, improves their heart targeted delivery ability. In a rat model of myocardial ischemia-reperfusion injury, tannic acid-modified (TANNylated) proteins are mostly internalized at myocardium rather than adsorb on endothelial layers in blood vessels. As a result, TANNylated basic fibroblast growth factor significantly reduced infarct size and recover cardiac function. |
| 저자 | 도민재, 이해신, 신미경 |
| 소속 | KAIST |
| 키워드 | Tannic acid; drug delivery; AAV |
