| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Bio-imaging for Targeted Delivery of Hyaluronic Acid Derivatives to The Liver in Cirrhotic Mice Using Quantum Dots |
| 초록 |
Liver cirrhosis is one of the representative liver diseases and a major cause of morbidity and mortality worldwide. In this work, real time bio-imaging of hyaluronic acid (HA) derivatives was carried out using quantum dots (QDots) to assess the possibility of HA derivatives as novel target specific drug delivery carriers to the liver in cirrhotic mice. According to in vitro cell culture tests, HA-QDot conjugates were taken up more to liver disease cells of hepatic stellate cells and hepatoma cells than normal hepatocytes. Furthermore, after tail vein injection, HA-QDot conjugates were target-specifically delivered to the cirrhotic liver with a slow clearance longer than 8 days. The results were thought to reflect the possibility of HA derivatives as novel drug delivery carriers for the treatment of various liver diseases including hepatitis, liver cirrhosis, and liver cancer. |
| 저자 |
김기수1, 허원희2, 박상준1, 홍성우2, 윤승규2, 한세광1
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| 소속 |
1포항공과대, 2가톨릭대 |
| 키워드 |
Hyaluronic acid; Quantum dots; Bio-imaging; Liver cirrhosis; Target delivery
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| E-Mail |
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