화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터)
권호 46권 2호
발표분야 의료용 고분자 부문위원회 Ⅰ,Ⅱ
제목 Black Phosphorus/Hyaluronate Complex as a Copper Chelating Agent for the Treatment of Wilson Disease
초록 Wilson disease (WD) is a genetic disorder of copper storage, resulting in pathological accumulation of copper in the body. Because symptoms are generally related to the liver, chelating agents capable of capturing excess copper ions after targeted delivery to the liver are highly required for the treatment of WD. Here, we developed hyaluronate-diaminohexane/black phosphorus (HA-DAH/BP) complexes for capturing copper ions accumulated in the liver for the treatment of WD. HA-DAH/BP complexes showed high hepatocyte-specific targeting efficiency, selective copper capturing capacity, excellent biocompatibility, and biodegradability. HA enhanced the stability of BP nanosheets and increased copper binding capacity. In vitro cellular uptake and competitive binding tests verified targeted delivery of HA-DAH/BP complexes to liver cells via HA receptor mediated endocytosis. The cell viability test confirmed the high biocompatibility of HA-DAH/BP complexes. Taken together, HA-DAH/BP complexes would be an efficient copper chelating agent to remove accumulated copper in the liver for the WD treatment.
저자 김성종, 한세광
소속 포항공과대
키워드 Black phosphorus nanosheets; Hyaluronate; Chelating agent; Wilson disease
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