| 초록 |
Among the visible light, short wavelength like green light can be widely used in photomedicine due to high energy. However, there are limitations when short wavelength light is irradiated because of low penetration into tissue and cell damages. The limitations can be improved by loading the UC dye can covert low frequency into higher frequency on hyaluronic acid-based nanoparticles. The successful preparation of HA-PCL/UC NPs was confirmed by DLS and TEM, and stability was confirmed by UV-visible spectroscopy. By UC analysis, NPs steady emitted green light, and further analysis in porcine skin tissue dispersant showed the applicability of our NPs in real skin tissue. Based on these results, our HA-based NPs are appropriated for transdermal delivery of UC dye and can complement the barriers of short wavelength with low penetration for effective phototherapy in the skin. |
