| 초록 |
In this presentation, we designed DNA-based nanoconstructs for anti-cancer therapy by using unique DNA such as i-motif DNA and G-quadruplex. For capturing target biomolecule, we prepared nanoconstructs consisting of a DNA-amplified aptamer with a biocompatible polymer backbone. The designed polymer-DNA amplified aptamer nanoconstructs (PA-aNCs) were successfully applied to alleviate tumor growth and VEGF-induced retinal vascular hyperpermeability in vivo through the highly effective capture of human VEGF as a target molecule. We also report the design, construction, and operation of a functional DNA-decorated dynamic gold (Au) nanomachine as a therapeutic agent for triple combinatorial anti-cancer therapy. By employing i-motif and G-quadruplex DNA, the combinatorial chemo, photodynamic, and photothermal therapeutic effects of the functional DNA-decorated Au nanomachines were evaluated in vitro and in vivo using a triple negative breast cancer model. |
