| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Application of Tropolone-encapsulated chitosan nanoparticles |
| 초록 |
Tropolone has been widely used as food additive. However, utilization of tropolone as preserved agent has been limited because of short half-life. To overcome these obstacle, tropolone was encapsulated to chitosan-graft stearic acid micelle (CSA), which may lead to sustained release of tropolone. The chemical structure of CSA was analyzed by 1H-NMR. Moreover, tropolone-loaded CSA nanoparticles (CSAT) were prepared by evaporation method. The contents, encapsulation efficiency and release behavior of tropolone from CSAT were confirmed by UV-vis spectrophotometer. Its particle size and morphological property of CSA and CSAT were confirmed by DLS and TEM. Moreover, cytotoxicity of CSA and CSAT were confirmed by MTT assay in human embryo kidney (HEK 293) cell line. These results suggest that CSA micelle is exceptional drug carrier for sustained release of tropolone. |
| 저자 |
홍웅길1, 안준혁1, 정경원2, 박준규3, 심왕근1, 나재운1
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| 소속 |
1순천대, 2조선이공대, 3시지바이오 |
| 키워드 |
Tropolone; Chitosan; Nanoparticle; Sustained releas
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| E-Mail |
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