| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
우수외국인연구자세션 |
| 제목 |
Dual pH/Ultrasound-Responsive Sonotheranostic Extracellular Vesicles for Efficient Chemo-sonodynamic Cancertherapy and Photoacoustic Imaging |
| 초록 |
Sonodynamic therapy (SDT) is a new therapeutic for noninvasive cancer treatment using ultrasound (US) to penetrate and activate sonosensitizers. Extracellular vesicles (EVs) were employed as biocompatible nanocarriers for drug delivery. Herein, EVs were utilized as dual stimuli-responsive carriers to deliver indocyanine green (ICG)(sonosensitizer/photoacoustic imaging agent), paclitaxe l(PTX)(chemo drug), sodium bicarbonate (SBC)(pH-responsive) into tumor cells. The endo/lysosomes acid pH environment bursted EV membrane by CO2 bubbles generation from the SBC and facilitated the release of ICG and PTX, and it was increasing when treated with US. SBC-EV(ICG/PTX) exhibited efficient anticancer activity against breast tumor cells and the accumulation of SBC-EV(ICG/PTX) in tumor-bearing mice was demonstrated by high-resolution PA imaging. SBC-EV(ICG/PTX) are promising sonotheranostic nanoplatforms for safe and efficient photoacoustic imaging and chemo-sonodynamic combination cancer therapy. |
| 저자 |
NGUYEN CAO THUY GIANG1, JI HEE KANG2, WANGYU KIM3, JUNHA LIM3, SU JIN KANG1, QUAN TRUONG HOANG1, WON JONG KIM3, WON JONG RHEE1, CHULHONG KIM3, YOUNG TAG KO2, MIN SUK SHIM1
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| 소속 |
1Incheon National Univ., 2Gachon Univ., 3Pohang Univ. of Science and Technology |
| 키워드 |
extracellular vesicle; sonodynamic cancer therapy; combination therapy; pH-sensitive release; photoacoustic imaging
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| E-Mail |
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