| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Vascular endothelial growth factor-induced angiogenesis and experimental corneal neovascularization are successfully suppressed by using apatinib-loaded nanoparticles |
| 초록 |
Pathological angiogenesis is one of the major symptoms of severe ocular diseases, including corneal neovascularization. treating corneal neovascularization. In this study, we aimed to investigate whether nanoparticle-based delivery of apatinib, a selective inhibitor of vascular endothelial growth factor(VEGF) receptor 2, inhibits VEGF-mediated angiogenesis. In a rat model of alkali burn injury-induced corneal neovascularization, a subconjunctival injection of apatinib-loaded HSA-PEG (Apa-HSA-PEG) nanoparticles decreases in neovascularization compared to free apatinib solution. These in vitro and in vivo results demonstrate that apatinib-loaded nanoparticles may be promising for the prevention and treatment of corneal neovascularization-related ocular disorders. |
| 저자 |
조희주, 정재백, 임수연, 김다훤, 김동민, 정지훈
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| 소속 |
성균관대 |
| 키워드 |
Apatinib; vascular endothelial growth factor; HSA-PEG; corneal neovascularization
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| E-Mail |
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