| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
정밀화학_포스터 |
| 제목 |
Synthesis of hyaluronic acid based protease degradable hydrogel |
| 초록 |
Degradable hydrogels are an important advanced materials in the field of biomedical applications for the purposes of tissue engineering and drug delivery. This presentation describes a method for preparing hydrogels degradable by alpha-chymotrypsin. The protease degradable hydrogel is composed of acrylated hyaluronic acid crosslinked by a peptide crosslinker containing a proteolytic degradation site. Hyaluronic acid was used because of enhanced biocompatibility and CD44 targeting for cancer therapy. Proteolytic degradation site is a peptide that sequence ‘CYKC’ reacted by alpha-chymotrypsin. Two thiol groups from terminal cysteines can be crosslinked with acrylated hyaluronic acid by thiol-ene click reaction. We envision that these protease degradable hydrogels are useful for tissue engineering and drug delivery. |
| 저자 |
박경은, 신동식
|
| 소속 |
숙명여자대 |
| 키워드 |
Protease degradable hydrogels; alpha-chymotrypsin; hyaluronic acid
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| E-Mail |
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