| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Genetically Engineered Polypeptide-based Nanostructures for Theragnosis |
| 초록 |
Polymeric nanostructures for theragnosis were developed to simultaneously detect and treat a disease. Especially, imaging and inhibition of neovascularization induced by uncontrolled angiogenesis are of interest to treat various diseases. We report herein the self-assembled nanostructures of genetically engineered fusion proteins, which were composed of penta-helices for the formation of coiled-coils, elastin-based polypeptide with stimuli-responsiveness for non-chromatographic purification tags and membrane-receptor targeting peptides for anti-angiogenesis. Functional peptides of the nanostructures were exposed to the aqueous environments, facilitating specific molecular interactions against the receptors and inhibition of neovascularization, as confirmed by enzyme-linked immunosorbent assay and fluorescence imaging via tubing assay of human umbilical vein endothelial cells. Conclusively, these self-assembled nanostructures would be potential as all-in-one theragnostic nanostructures. |
| 저자 |
강민정1, 이재상2, Aamna Basheer1, 임동우2
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ. |
| 키워드 |
Genetically Engineered Polypeptides; Stimuli-responsiveness; Self-assembly; Nanostructures; Theragnosis
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| E-Mail |
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