| 초록 |
Zwitterion, which contain both positive and negative charge groups, have strong electrostatic interaction with water molecule that can form solvation shell on its surfaces at pH 7.4. The solvation shell has function of thermodynamical barrier from protein adsorption on surface as known, however, the effect of drug molecule’s release behavior by solvation shell still has not been well-known. Here, we designed branched-polyethyleneimine (bPEI) based sulfobetaine zwitterion nanoparticles (ZWNP) and investigated solvation shell of ZWNP by rheologically and thermodynamically. The ZWNPs showed strong anti-fouling properties (minimum for 72 h) due to the slow downed translational motion of water molecules than at the other pH conditions. Then our group synthesized NO releasing ZWNP which showed sustained release profile in pH 7.4 (at least 80 h) while showed different release profile in different pH (burst release in pH 5.5, non-release in pH 10). |
