| 초록 |
Local cell injury and inflammation in implantation sites lead to subsequent serious complications still unresolved challenge of various medical devices with blood-contacting applications. In this study, inspired by the role of galectin-1(GAL-1) in inflammatory and immunomodulatory processes, we constructed a multifunctional surface with GAL-1 protein-rich natural supported lipid bilayer coating to enhance antifouling properties, promote endothelial cell activity and anti-inflammatory effects. The constructed surface showed the expected antifouling activity by resisting the adhesion of proteins, platelet, and bacteria. Notably, the surface gal-1 protein shows the ability to promote endothelial function and inhibit smooth muscle cell proliferation. In addition, the GAL-1 presenting surface reduced smooth muscle cell and macrophage-released inflammatory cytokines. This study demonstrated multifunctional surfaces with efficient and straightforward construction for blood-contacting devices. |
