| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
Virtual Lightning Session |
| 제목 |
Fabrication of PAN Nanofibers Loaded with Diclofenac Sodium Salt for Antibacterial and Anti Inflammatory Applications |
| 초록 |
Diclofenac sodium (DLF) salt loaded polyacrylonitrile (PAN) nanofibers were successfully prepared by electrospinning. The inclusion of DLF in PAN nanofibers increased the nanofiber diameter from ~200 nm to ~500 nm, proportional to the amount of DLF loaded into it. FTIR spectra confirm the entrapment of the DLF into the PAN nanofibers. X-ray diffraction pattern showed that PAN nanofibers had caused the misalignment in the polymeric chains of the PAN, thus resulting in a decrease of the peak intensity at 2θ = 17°. The DLF loaded PAN nanofibers were efficient against the gram-positive Staphylococcus aureus and gram-negative Escherichia coli. DLF loaded PAN nanofiber showed good cell viability ~95% for L929 cells in more extended incubation periods. The release profile indicates that the DLF release from the PAN nanofibers was slow and is beneficial as PAN nanofiber will retain the bioactive agent throughout their useful life. Cell adhesion micrographs show that cell-cell interaction is stronger than the cell-material interaction. This type of weak cell interaction with the wound dressing is particularly advantageous, as this will not disturb the wound surface during the nursing of the wound. |
| 저자 |
Muhammad Nauman Sarwar, Ick Soo Kim
|
| 소속 |
Shinshu Univ. |
| 키워드 |
- |
| E-Mail |
|
