| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 봄 (04/07 ~ 04/09, 대전컨벤션센터) |
| 권호 |
46권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation and characterization of chitosan-based hydrogels for colon-targeted drug delivery applications. |
| 초록 |
The pH-/thermal-responsive hydrogels for colon-targeted drug delivery applications were prepared based on ionic cross-linked of Polyacrylic acid (PAA), Norbornene-modified Chitosan (CsNb) then chemically crosslinked with bisTetrazine- Poly(N-isopropyl acrylamide) (bisTz-PNIPAM). PAA provided the system’s pH-responsiveness property with least swelling and drug release at acidic, meanwhile strong swelling and release in alkaline environment. BisTz-PNIPAM crosslinker led to increasing of drug loading content because of more porosity structure, and controlled the release based on shrinkage mechanism. Hydrogels provided highly drug loading content, performed the least swelling, least drug release fraction at pH 2.2 (8.5%), rapidly swelling and enhanced release at pH 7.4 (95%). These above features made hydrogels the suitable carrier for colon targeted drug delivery. |
| 저자 |
조성우, Hoang Thi Huong, 이시윤, 안병현, 임권택
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| 소속 |
부경대 |
| 키워드 |
hydrogels; drug delivery;
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| E-Mail |
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