| 초록 |
Photodynamic therapy and chemotherapy are types of cancer treatment. In this study, we designed a photosensitizer (RL) to achieve the synergy of photodynamic therapy and chemotherapy. RL consists of photosensitizer part with high singlet oxygen quantum yield and prodrug part activated by redox stress (GSH and H2O2) in heterogeneous tumors. In solution study, it showed the increased fluorescence at 430 nm by releasement of camptothecin(CPT) under redox stress conditions. And it exhibited good singlet oxygen quantum yield (ΦΔ = 0.46) under 530 nm LED irradiation. In vitro, we studied its low dark toxicity in CT26 cells (murine colon cancer cell) by MTT assay. And we expect therapeutic synergy of its photodynamic/chemo therapeutic ability in redox stress environment of heterogeneous tumors. Thus, we suggest the strategy of photodynamic/chemo synergistic therapy, which can increase the therapeutic efficiency of cancer cell. |
