| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Stability of lyophilized poly(D,L-lactide-co-glycolide) nanoparticles containing coenzyme Q10 |
| 초록 | Lyophilization has been studied to increase the stability and store-ability of poly(D,L-lactide-co-glycolide)-nanoparticles (PLGA-NP). Purpose of this study is to stabilize coenzyme Q10 loaded PLGA-NP by lyophilization with several cryoprotectants. PLGA-NP was prepared spontaneous emulsification solvent diffusion (SESD) method using poly(vinyl alcohol) and tween 80 as surfactants.1 Result of this study showed that addition of sucrose or maltose as a cryoprotectant was very efficient to preserve the inherent properties of PLGA-NP (Fig. 1). The existence of cryoprotectant such as sucrose or maltose above 0.2% is effective for cryoprotection of PLGA-NP. Figure 1. Effect of cryoprotectant concentration on the size of PLGA-NP before and after lyophilization at -50℃. Reference 1. H. Murakami, M. Kobayashi, H. Takeuchi and Y. Kawashima, Int. J. Pharmaceutics, 187, 143 (1999) |
| 저자 | 최민수1, 한희동1, 성하수1, 박은석2, 신병철1 |
| 소속 | 1한국화학(연), 2성균관대 |
| 키워드 | lyophilization; PLGA; PVA; sucrose; maltose |
