| 초록 |
Herein, we report a facile strategy for the synthesis of artificial antibodies consisting of luminescent transition metal dichalcogenide (TMD) nanosheets and nonbiological polymeric recognition phases for the selective detection of the target pathogens, Escherichia (E.) coli O157:H7 and Staphylococcus (S.) aureus. TMD nanosheets with a dextran phase at their interface selectively recognized S. aureus, whereas the nanosheets bearing a carboxymethylated dextran phase recognized E. coli O157:H7 with high binding affinity. The mechanism responsible for the selective recognition against the specific bacteria was thoroughly identified by experiments and molecular dynamics simulations. Moreover, the MoSe2 artificial antibodies selectively killed the pathogenic bacteria under near-infrared irradiation, allowing effective treatment of pathogen infected wounds. This new artificial antibody approach can be extended to recognize a variety of other biomolecules for selective sensing and therapy. |
