| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 봄 (05/12 ~ 05/14, 부산 벡스코(BEXCO)) |
| 권호 |
25권 1호 |
| 발표분야 |
포스터-전기화학 |
| 제목 |
A spheroid-forming conductive platform that electrochemically detects anticancer effects of curcumin in a multicellular brain cancer model |
| 초록 |
This study reports a novel platform that capable for highly efficient formation of three-dimensional (3D) cancer spheroids and precise real-time assessments of the anticancer effects of curcumin in a brain tumor co-culture model. A highly conductive gold nanostructure (HCGN) was generated to facilitate cancer spheroid formation without using anti-cell adhesion molecules. A neuroblastoma and glioblastoma co-culture model were formed on HCGN with a specific cell-to-cell ratio and their redox behaviors were assessed without distracting the distinct 3D structure of the multicellular spheroids. Using electrochemical signals as an indicator of spheroid viability, the effects of potential anticancer compounds on co-cultured spheroids were measured. The detection was sequentially done more than ten times for both short- (63 hours) and long-term cultivation (144 hours) without damaging the spheroids, enabling real-time, non-destructive pharmacokinetic analysis of various drug candidates. |
| 저자 |
SUHITO INTAN ROSALINA, 김태형
|
| 소속 |
중앙대 |
| 키워드 |
brain cancer; drug screening; electrochemical assessment; gold nanostructure; multicellular spheroids
|
| E-Mail |
|
