| 학회 |
한국화학공학회 |
| 학술대회 |
2016년 가을 (10/19 ~ 10/21, 대전컨벤션센터) |
| 권호 |
22권 2호, p.1788 |
| 발표분야 |
생물화공 |
| 제목 |
A Robust Scaffold for Multimodality Using a Plasmonic Gold Core and a Mesoporous Fe3O4 Shell |
| 초록 |
Multifunctional nano-systems are an enticing approach towards designing nanoparticles with desired characteristics, which emerge from interaction between various components of the system. Nano-particle based multi-modal contrast agents can offer various complementary properties. and hence, can be detected by several in vivo imaging techniques. CT and MR image acquisition and registration are foremost step in radiation therapy planning. These provide valuable information in target definition and determination of radiation dosage. In this study, we have demonstrated a one-pot approach for the synthesis of Au core/ porous-Fe3O4 shell nanoparticles (AuFe NPs) for MR/CT dual imaging, loaded with doxorubicin (Dox). The particle surface was coated with polyethylene glycol and matrix metalloproteinase (MMP) peptide for targeting. The gold core provides a strong X-ray absorption and the Fe3O4 shell enables the MR imaging. The drug loading capacity of the porous iron oxide nanoshell was also demonstrated and a surface quenching effect of the gold nanoparticles is proposed and correlated with the release of Dox from the porous core/shell system. |
| 저자 |
Aastha Kukreja, 강병훈, 김현욱, 장은지, 손혜영, 박광열, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
바이오칩/나노바이오공학 |
| E-Mail |
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| VOD |
VOD 보기 |
| 원문파일 |
초록 보기 |
