| 초록 |
Chemotherapy has been the common treatment modality in anticancer therapies over past decades. However, chemotherapy has several inevitable limitations such as severe side effect. One promising strategy to enhance the therapeutic efficacy is the combination with other treatment modality such as oxidation therapy and photothermal therapy (PTT). In this work, we developed dual imaging-guided oxidative-photothermal combinational nanotherapeutics (OPCN) consisting of amphiphilic polymers conjugated with ZnPP (zinc protoporphyrin) as a HO-1 inhibitor and fluorescent IR820 as a photothermal agent, respectively. Combination of OPCN and NIR laser irradiation markedly increased temperature and exerted significant toxicity through induction of apoptotic cell death. In a mouse model of xenografts, tumors were identified by the strong fluorescence and photoacoustic signal. We anticipate that OPCN has great potential for dual imaging-guided oxidative-photothermal combinational anticancer therapy. |
