| 초록 |
Although thermal ablation techniques such as radiofrequency, laser, microwave, and high-intensity focused ultrasound commonly utilize for cancer treatment, those conventional ablation techniques can cause side effects, damage to surrounding tissues, blood vessels, and lymphatic vessels. Electrical ablation can treat a tumor with strong electric fields. The generated electronic field make nano-scale pores in the cell membrane, leading to the apoptotic cell death of cancer cells. The electrical ablation can also induce an anti-tumor immune response through immunogenic cell death (ICD) mechanism. Here, we demonstrate the synergistic effect of electrical ablation and nanoparticles in cancer treatment. The nanoparticle was designed for cancer immunotherapy under image-guidance. The core-shell structure nanoparticles were synthesized and surface-modified with adjuvants to the surface. |
