| 초록 |
Injectable hydrogels offer a wide range of attractive benefits, as an easy-to-use medical device for various applications, including drug delivery and tissue engineering. In this work, hydrogels were fabricated by modification of alginate with tyramine and subsequent enzymatic crosslinking reaction. The modified alginate was analyzed by ATR, 1H-NMR in order to confirm the introduction of tyramine. Rheological properties were also tested according to adjust the amount of H2O2, HRP and concentration of modified alginate solutions. As a result, the modified hydrogels were successfully synthesized. The results for gelation time and mechanical strength revealed that both the rate and degree of cross-linking in hydrogels were fairly well controlled by changing the H2O2 and HRP concentrations. From the results of these experiments, it is concluded that the hydrogels has sufficient value for biomedical applications. |
