| 초록 |
Lipid flip-flop or transbilayer is an area of significant biological importance. The packing state of lipid in real system, which is a consequence of multiple factors, is potential to cause defect sites within membrane. These defects would be membrane channels which regulate many biological functions, including of lipid translocation. Since the flip-flop is a slow dynamics process, Neutron reflectivity is suitable tool to monitor the lipid composition on each layer as a function of time. We would like to investigate the effect of unsaturated lipids as 1) how the dynamics of lipid diffusion process is controlled by the membrane packing, and as 2) whether flip-flop can be induced from only one side of the membrane bilayer. These asymmetric bilayers were characterized Neutron reflectivity to investigate the absolute composition and the relative location of lipid molecules within the bilayer and at its interfaces. |
