| 초록 |
Mesoporous silica nanoparticles (MSNs) have emerged as a nanocarrier for cancer therapy and imaging owing to their high drug loading capability, excellent biocompatibility, and surface characteristics for facile chemical modification. Especially, MSN allows for the site-specific delivery of drugs by introducing stimuli-responsive gatekeepers. Of stimuli, reactive oxygen species (ROS) have been considered as promising candidates owing to its highly reactive nature. In this study, we developed ROS-responsive MSNs (R-MSNs), consisting of a gadolinium (Gd)-DOTA based ROS-responsive gatekeeper and Ce6-based ROS-generator for magnetic resonance (MR) imaging-guided photodynamic chemotherapy. The physiological characteristics of R-MSN were investigated using TEM, DLS, FT-IR and XRD. Collectively, these results suggest that R-MSNs are promising drug carrier for MR imaging-guided photodynamic chemotherapy. |
