| 초록 |
Electrospinning has drawn attention mainly due to its ECM-mimicking biomimetic structure, facileness of fabrication method, and diverse techniques to modify the properties of nanofibers. Also, the electrospun scaffolds can serve as templates for substrate-mediated therapeutics delivery for localization, increasing efficacy, controlling release profile and reducing toxicity, which are crucial factors in developing therpauetics delivery systems. Herein, the 3D compressible and elastomeric nanofibrous scaffold is presented. It can withstand pressures exerted at the implanted site and keep its macro- and micro-morphological characteristics. As therapeutic substances, AAV-based vectors were chosen due to their safety (i.e. lower immunogeneicity, non-pathogenicity) and high delivery efficiency to the majority of therapeutically relevant cells, including stem cells and even cancer cells. In conclusion, the AAV-delivering 3D electrospun nanofibers discussed in the current study hold a great potential as gene delivery vehicles which could be applied in numerous therapies via the synergistic combination of advanced scaffold technologies and talented gene carriers. |
