| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Dendritic Assembly of Gold Nanoparticles for Enhanced Cellular Delivery of siRNA |
| 초록 |
RNA interference (RNAi) has received growing attention for possibility of treat hard to cure disease and gene-related disease in gene therapy due to gene silencing effect. Herein,Successful cellular delivery of synthetic siRNA depends mainly on the capability of a carrier to form a stable complex with siRNA, which can provide efficient protection of the siRNA from enzyme-mediated degradation and improved cellular uptake. In this study, dendritic gold nanoparticles (Au@MC) were applicated for siRNA delivery. .Among various formulations of dendritic gold nanoparticles, Au@MC-2/siRNA complex exhibited efficient gene suppression in the absence and presence of serum with low cytotoxicity. It is anticipated that particular grooves having Au@MC have a chance at siRNA protection against enzymatic digestion, leading to serum stability and improved gene silencing effect. Therefore, Au@MC can be considered as a potential candidate Nanodrugs for effective and non-toxic siRNA delivery carriers. |
| 저자 |
김병덕, 박채은, 임수연, 김다훤, 황위보, LYU SIYAN, 정준구, 신주화, 이지현, 유빈, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
non-viral gene delivery; siRNA; dendritic gold nanoparticles
|
| E-Mail |
|
