| 초록 |
In case of intense bleeding, hemostasis is essential for survival. In order to fabricate a powder-type hemostatic agent with effective hemostatic properties, the blood absorption rate was improved by crosslinking chitosan and starch, and thrombin and Ca ions were introduced to induce rapid blood clotting upon contact with blood. Polyvinylpyrrolidone (PVP) was introduced to improve tissue adhesion property and prevent rebleeding when a large amount of bleeding. The PVP coating improved tissue adhesion, reduced the coagulation time by 3.5 times due to the introduction of blood coagulation factors, and showed the formation of more thrombin. In vivo animal studies using a liver bleeding model in SD rats showed faster hemostasis and less bleeding. The chitosan/starch/PVP powder has excellent hemostatic and tissue adhesion properties. It is expected to be applied as a surgical local hemostatic agent. |
