| 초록 |
Most neuroprosthetic devices implanted into the central nervous system (CNS) face limitations in longevity and functional reliability due to undesired inflammatory host tissue response initiated upon device insertion. At the implant site, activated microglia, reactive astrocytes, macrophages form glial sheath that can encapsulate and isolate the electrode from the surrounding tissue. In addition, neuronal loss and neurite degeneration occur surrounding the electrode. As a result, the performance of the implanted probe decreases over time. We developed substance P/Heparin-conjugated PLCL polymer. Hep/SP-PLCL coating on the neural probe reduces inflammatory responses and glial sheath formation, while increasing neuronal density in the probe-brain interface. Additionally, neural stem cells recruited by Hep/SP-PLCL have the potential to enhance neurogenesis and regenerate tissues in the injury area caused by the probe insertion. |
