| 초록 |
Although cancer immunotherapies have received extensive attention and become mainstream strategies for treating cancer, the therapeutic efficacy of cancer immunotherapy is mainly limited by the immunosuppressive tumor microenvironment (TME). To overcome such obstacles in the TME, we designed and evaluated nanoengineered synthetic immune niches that could modulate the immunosuppressive TME in a spatiotemporal manner for enhanced cancer immunotherapy. When nanoengineered synthetic immune niches were applied as a local postsurgical treatment, both systemic antitumor immunity and a memory T cell response were generated, and the recurrence and metastasis of tumors to lungs and other organs were significantly inhibited. The nanoengineered synthetic immune niches are expected as an immunotherapeutic platform that can reshape immunosuppressive TMEs and synergize cancer immunotherapy with checkpoint therapies, with minimized systemic toxicity. |
