| 초록 |
Drug and gene delivery through intravascular injection spread throughout the body. So, Drug and gene delivery to target tissue locations is difficult. Therefore, direct injection into the target tissue is mostly for local delivery. However, without specific mediator, direct injection into the target tissue is difficult for sustained release because of the rate of diffusion of drugs and genes. Because of this, drug and gene delivery through mediators is essential. But an incision is necessary when the mediator is implanted through surgery. In order to minimize the incision site, injection should be possible. Therefore, this study was carried out by designing polyelectrolyte for the above-mentioned local & sustained drug and gene delivery. To produce the desired polyelectrolyte, we studied how to control the release rate of drugs and genes and reduce the immune response by controlling the combination of various materials applicable to the living body. |
