| 초록 |
Recently, mRNA has been used as a therapeutic for the effective expression of therapeutic proteins. As carrier materials for delivering mRNA via a non-viral method, polymers, peptides, and lipids have been developed. Among these methods, lipid nanoparticles (LNPs) have been studied most actively and can be said to be one of the most powerful platforms. However, previous LNPs formulations have limitations as vaccine platforms such as inducing toxicity and short duration of efficacy. Therefore, it is necessary to develop a technology that can effectively deliver mRNA using a small amount of carrier, reducing the toxicity of the carrier, or prolonging in vivo half-life. Herein, we introduce advanced technologies that can efficiently load mRNA to LNPs, as well as enhance the delivery and expression in cells. We anticipate that the method will provide an effective platform for the delivery of therapeutic mRNA for applications such as vaccines for infectious diseases and cancer. |
