| 초록 |
Transdermal drug delivery is a non-invasive drug administration by bypassing the first metabolism, resulting in high efficacy as well as great convenience. However, the skin penetration of drugs is challenging because of barrier function of stratum corneum of so-called ‘brick-and-mortar’ structure. Pectin that is derived from plant cell wall is a biocompatible polysaccharide and widely used in pharmaceutics and food industry. In this work, pectin nanogels were fabricated via photo-crosslinking and characterized. The prepared pectin nanogels has a uniform size of ~200 nm and good cytocompatibility. In addition, in skin penetration test using a Franz diffusion cell, the nanogels were delivered into dermis through stratum corneum, indicating the pectin nanogel has a great potential as a transdermal drug carrier. |
