| 초록 |
Continuously spun hydrogel microfibers can exhibit great potential in embolizing vascular malformations (e.g., aneurysms) without resulting in complications like premature gelation or non-crosslinking of hydrogels. However, accomplishing this process is challenging due to the absence of biocompatible and stable hydrogels and the difficulty in continuously spinning the microfibers in extreme endovascular environments. This study develops a double-crosslinked alginate-based hydrogel with tantalum nanopowder (DAT) that employs the synergistic effect of covalent crosslinking and ionic crosslinking. Furthermore, an effective strategy using microfluidic device capable of continuously spinning hydrogel microfibers by in situ photocrosslinking in endovascular environments. As an embolic material, DAT exhibits promising characteristics, such as non-dissociation, non-swelling, and constant mechanical strength in blood, including excellent cyto- and hemo-compatibilities. DAT microfibers can safely, uniformly, and completely fill aneurysms without generating microscopic fragments or clogging demonstrating itself as an effective embolization strategy. |
