| 초록 |
In this work, water-insoluble and biocompatible hydrogel nanoweb was prepared via electrospinning of sodium carboxymethyl cellulose/poly(ethylene glycol) (CMCNa/PEO). After removal of PEO, the CMCNa in the nanoweb was crosslinked by FeCl3 as a crosslinker. The molecular entanglements of the solutions decreased with the increase of PEO concentration due to its relatively small size. The fiber diameter was decreased as the PEO content increased. After extraction of PEO, the diameter was significantly reduced. The surface of the nanowebs became bumpy after crosslinking and fiber diameter increased with the increase of the crosslinking time. The chemical states of the nanowebs were analyzed by FT-IR spectra. The cytotoxicity of nanoweb was also evaluated. Furthermore, the drug release behavior was compared between hydrogel film and nanoweb. Compared with the film, the nanoweb showed longer and more sustained release because of its high crosslinking density and large surface area. |
