| 학회 | 한국화학공학회 |
| 학술대회 | 2008년 가을 (10/23 ~ 10/24, 부산 BEXCO) |
| 권호 | 14권 2호, p.3614 |
| 발표분야 | 제5회 약물전달(DDS) 기술 심포지엄 |
| 제목 | pH and/or Temperature Responsive Micelles and Hydrogelsfor Drug Delivery and Molecular Imaging |
| 초록 | In this presentation, we would like to introduce some recent works on the pH and/or temperature responsive micelles and hydrogels for controlled drug delivery and molecular imaging applications. Micelles In our system, the pH-responsive polymeric micelles were composed of hydrophilic methyl ether poly(ethylene glycol) (MPEG) and pH-responsive degradable poly(β-amino ester) segments. This diblock copolymer, which could self-assemble nano-sized micelles with core-shell structures under aqueous conditions, showed noticeable the pH-dependent micellization-demicellization behavior. Hydrogels we have also investigated an injectable carrier of pH/ temperature sensitive hydrogel, penta-block copolymer PAE-PCL-PEG-PCL-PAE, for controlled drug/protein delivery. The cationic nature of PAE is used as the second function to make the ionic complexes with anionic biomolecule loaded into the hydrogel such as insulin. As a result, the release of drug/protein from this hydrogel device can be controlled by the degradation of copolymer. |
| 저자 | GuangHui Gao, 김민상, DaiPhu Huynh, 이두성 |
| 소속 | 성균관대 |
| 키워드 | pH/or Temperature responsive; Micelle; Hydrogel |
| VOD | VOD 보기 |
| 원문파일 | 초록 보기 |
