| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 봄 (04/30 ~ 05/02, 제주국제컨벤션센터) |
| 권호 | 18권 1호 |
| 발표분야 | 한국공업화학상 수상자강연 |
| 제목 | Nanogels, internal networks for drug delivery system |
| 초록 | Nanogels, aqueous dispersion of hydrogel nanoparticles, are a received great interest due to their high water contents and small particle size. Especially, stimuli-responsive nanogels can change their volume significantly in response to small alterations of environmental parameters such as pH-response of polyelectrolyte hydrogels on the ionization of the network. In this talk, diverse morphologies of self-assembled nanostructures of amphiphilic poly(amino acid)s, and their self-aggregates of cross-linked micelles will be discussed for biomedical applications such as drug delivery carriers and MRI contrast agents. It is shown in Figure 1a that various hydrophobic groups (alkyl, PLA, hydrophobic nanoparticles) were grafted on hydrophilic poly(amino acid)s backbones, which formed diverse morphologies of self-aggregates including sphere, cylinder, tube, disk, and vesicle. Nanogels can be prepared first by cross-linking micelles and conversing hydrophobic core to hydrophilic core. Second, the self-aggregates of PEG-PSI were cross-linked by reaction of PSI with diamine cross-linkers. Finally, Figure 1b shows that hydrophobic PSI was converted into hydrophilic poly(aspartic acid)s (PAsp) to obtain PEG-PAsp nanogels. The PEG-PAsp nanogels had small particle size in range of 80~130 nm. PEG-PAsp nanogels can absorb 50 times volume of water as much as its polymer volume in SANS anaylsis. Nanogels formed by disulfide resembled the pH sensitive release of insulin and reversible cleavage in presence of reducing agents in tumer cells. The iron oxide loaded in cross-linked poly(amino acid)s showed the improved stability in aqueous solution, and higher MR contrast than commercialized agent. The stable bilayer of vesicle triggered drug release at milimolar concentrations of reducing agent which is relevant to the level of intracellular condition. After cellular uptake, drugs were translocated to nuclei in cancer cells as the highly stable and stimuli-responsive carriers and triggered drug release at target site. This research has been supported by Korea Research Foundation, BexPharm Co, Amore Pacific Co., Ministry of Health and Welfare, and Korea Research Institute of Bioscience and Biotechnology. Also thanks for technical assistance to Hanaro at KAERI and KBSI. References 1) Yang, H.M., et.al., Chem. Commun., 2011, 47, 12518-12520 ; Biomacromolecules, 2010, 11, 2866–2872. 2) Park, C. W., et.al, J. Polym. Sci. Part A, 2011, 49, 203. |
| 저자 | 김종득 |
| 소속 | KAIST |
| 키워드 | nanogel; drug delivery system |
