| 초록 |
Number of researchers developed to drug carriers composed of hydrophilic and hydrophobic substance. However, they had a problem that was led to sustained drug release in cancer cell, which was induced to side effect and inefficient therapy. To solve these problem, redox-sensitive polymeric micelle were synthesized by chemical reaction between lipoic acid (LA) and soluble chitosan (SC). Chemical structure of LA-grafted soluble chitosan (LSC) was confirmed by 1H-NMR and FT-IR. Also, Doxorubicin (DOX)-loaded LSC (DLSC) nanoparticle was prepared by dialysis method. Its drug contents (DC) and encapsulation efficiency (EE) from DLSC was calculated by using UV-vis spectrophotometer. To demonstrate redox-sensitive effect of DLSC, drug release behavior was accomplished in presence GSH. Moreover, Cytotoxicity was conducted by using MTT assay. These results suggest that redox-sensitive DLSC can apply as anticancer agent for cancer therapy. (NRF-2016H1D5A1910499). |
